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Systemic adverse effects appear to be uncommon based on available reports, but comprehensive adverse event profiles are lacking due to the paucity of large-scale clinical investigations

6 CPP-mediated systemic delivery of antidiabetic peptides through nasal administration Therapeutic proteins and peptides can be administered parenterally by intravenous or subcutaneous routes

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Elrefaey S, Massaro MA, Chiocca S, Chiesa F, Ansarin M

Finally, it is remarkable how sustained the response to ARA 290 appears to be